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When Ive looked at literature on methylene blue, Ive only found one case report of toxicity in humans

Side effects to tell your doctor about immediately are skin rashes, itching, hives, swelling of the tongue, lips, or face, blueish skin, chest tightness or pain, trouble breathing, wheezing, dizziness, or red, swollen, painful area on a leg (via the Cleveland Clinic)

The Recommended Dietary Allowance (RDA) for vitamin B12 The recommended amount of vitamin B12 for people who have received a diagnosis of B12 deficiency or have absorption difficulties may be higher than the RDA

The observed synergistic effect suggests that both macrophages and mast cells play a significant role in the early stages of atherosclerosis

Beyond that, using the thinnest needle that works for your situation, injecting slowly, and never forcing medication into tissue that feels resistant all protect long-term tissue health

WADA notes in FAQs that amounts of phenethylamines in food should not cause positive drug tests